Today, MXenes with fascinating electronic, thermal, optical, and mechanical features have been broadly studied for biomedical applications, such as drug/gene delivery, photothermal/photodynamic therapy, antimicrobials/antivirals, sensing, tissue engineering, and regenerative medicine. Our results indicate that PTT mediated by both few- and multi-layer MXenes significantly modulates the tumor progression through cells’ death by increasing the temperature, which holds particularly true for the bio-printed model. Moreover, we studied the effect of PTT on the migration of macrophages and endothelial cells toward cancer regions in both 3D models. After PTT, a significant reduction in the cell viability along with a notable increase in reactive oxygen species (ROS) was observed. We performed PTT on both cancer models using a non-toxic MXene concentration of 50 µg/mL. In this work, we investigated the effect of few- and multi-layer Ti3C2Tx MXenes mediated-PTT on two different 3D reliable breast cancer models such as conventional and bio-printed spheroids. We previously demonstrated that MXenes, new bioactive nanomaterials with promising photophysical properties, are capable to increase the efficiency of the targeted breast cancer photothermal therapy (PTT). Current therapies (e.g., chemotherapy) show numerous limitations due to the lack of selectivity and involved side effects, which urgently asks for novel approaches with enhanced tumor-killing efficacy. We welcome volunteers and new members to support our activities, events and serve on our Legislative, Fundraising, Education, Community Outreach, and Public Awareness committees.Globally, breast cancer is the most diagnosed invasive cancer among women. We also conduct satisfaction surveys to monitor the quality of services being received by people with intellectual and/or developmental disabilities called IM4Q. The Arc of Indiana County sponsors seminars, workshops, conferences, training, and fairs to increase public awareness on disability issues, provide resources, support, and education on topics relevant to our individuals and their families. We discuss disability issues with local legislators, develop action alerts, and advocate for the rights of individuals with intellectual, developmental, and other disabilities. The Arc works at the national, state, and local level to monitor laws and regulations that affect people with disabilities. Helping individuals live their best life! We encourage and support positive communication between parents, students, educators, and agencies, organizations, and service providers.įor adults with disabilities, we can provide information about supports, transition, employment, and services so you can make informed decisions to help you have the life you want in the least restrictive environment possible. Quality education and appropriate services require a collaborative effort. Assists families with planning their child’s transition to a new school or work environment.Helps families prepare for meetings with school and agency personnel.Assists in getting answers to questions and concerns about programs and resources for children and adults with disabilities and their families.Provides information, resources and guidance needed by families to help their children succeed.The Arc of Indiana County can assist parents and their children, as well as adults, in numerous ways. We believe that the earlier a child receives the appropriate programs and services, within the community, the greater the opportunity for the child to grow up happy and successful. The Arc of Indiana provides information, education and support for people with intellectual/developmental disabilities and for their families.
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